The purpose of this study was to compare the education and background, position characteristics, job responsibilities, job satisfaction, and well-being of Occupational Therapists (OTs) and Physical Therapists (PTs) to better understand the current state of affairs within the two professions. It is evident that there is a lack of awareness regarding the similarities and differences between these professions. Therefore, this study can aid in informing allied health professionals' patient referral management, prospective OT and PT students to understand the career demands, and healthcare consumers to seek appropriate medical management. This study used a mixed-methods, cross-sectional conventional mail survey design with 101 OT and 113 PT participants from throughout the USA.